HitPredict

Interactor 1: BMP4 (P12644)
Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
Gene: BMP4

Interactor 2: BMPR2 (Q13873)
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Gene: BMPR2

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.890

The method score is based on:

Property Details
Experiments 28126904, 7644468, 12045205, 7673243
Identification Methods pull down, affinity chromatography technology, coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~TGF_beta
Common GO terms GO:0001649 - osteoblast differentiation
GO:0003197 - endocardial cushion development
GO:0005615 - extracellular space
GO:0010628 - positive regulation of gene expression
GO:0030501 - positive regulation of bone mineralization
and 9 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 408
Hs

1 1038
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024