HitPredict

Interactor 1: HMDH2 (P12684)
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMG-CoA reductase 2) (EC 1.1.1.34)
Gene: HMG2

Interactor 2: NSG1 (P38837)
Protein NSG1 (INSIG homolog 1)
Gene: NSG1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.898

Property	Details
Experiments	16270032, 18467557, 37968396, 23306196
Identification Methods	affinity chromatography technology, biochemical, protein complementation assay, dihydrofolate reductase reconstruction
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	INSIG~Sterol-sensing
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0034399 - nuclear periphery
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1 1045 Sc			1 291
+	Sc
		520259 HMDH1_YEAST (5-1034): 0: 1547: 62.38		NSG1_YEAST (1-291): 2.44e-179: 497: 100.00