HitPredict

Interactor 1: RAD50 (P12753)
DNA repair protein RAD50 (EC 3.6.-.-) (153 kDa protein)
Gene: RAD50

Interactor 2: ATM (P38110)
Serine/threonine-protein kinase TEL1 (EC 2.7.11.1) (ATM homolog) (DNA-damage checkpoint kinase TEL1) (Telomere length regulation protein 1)
Gene: TEL1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26901759, 31073030, 30698745, 38180815
Identification Methods	anti tag coimmunoprecipitation, pull down, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0006302 - double-strand break repair and 1 others more... GO:0042162 - telomeric DNA binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1312 Sc			1 2787
+	Hs
		1031578 RAD50_HUMAN (1-1312): 2e-86: 310: 25.28		ATM_HUMAN (1656-2786): 0: 839: 24.61
+	Hs
		1031526 SMC1A_HUMAN (1-1287): 1.38e-59: 226: 11.78		ATM_HUMAN (1656-2786): 0: 839: 24.61
+	Dm
		1125447 RAD50_DROME (1-1306): 3.63e-67: 251: 24.47		ATM_DROME (1703-2785): 1.17e-157: 551: 20.83
+	Hs
		1272065 RAD50_HUMAN (1-1312): 2e-86: 310: 25.28		TRRAP_HUMAN (1737-2786): 1.42e-133: 475: 12.53
+	Hs
		1038112 SMC1A_HUMAN (1-1287): 1.38e-59: 226: 11.78		ATR_HUMAN (1739-2786): 8.98e-159: 554: 20.11
+	Hs
		1057437 SMC1A_HUMAN (1-1287): 1.38e-59: 226: 11.78		TRRAP_HUMAN (1737-2786): 1.42e-133: 475: 12.53
+	Hs
		944243 SMC1A_HUMAN (1-1287): 1.38e-59: 226: 11.78		PRKDC_HUMAN (1939-2786): 1.01e-127: 455: 19.16
+	Hs
		522655 MYH7_HUMAN (784-1202): 5.49e-18: 92.5: 9.31		TRRAP_HUMAN (1737-2786): 1.42e-133: 475: 12.53
+	Hs
		725085 MYH9_HUMAN (50-565): 3.03e-17: 90.2: 7.20		TRRAP_HUMAN (1737-2786): 1.42e-133: 475: 12.53
+	Hs
		551877 DESP_HUMAN (179-757): 9.93e-12: 72.3: 11.71		TRRAP_HUMAN (1737-2786): 1.42e-133: 475: 12.53
+	Hs
		551665 DESP_HUMAN (179-757): 9.93e-12: 72.3: 11.71		PRKDC_HUMAN (1939-2786): 1.01e-127: 455: 19.16
+	Hs
		725105 MYH10_HUMAN (45-667): 4.85e-21: 102: 10.17		PK3CA_HUMAN (2097-2701): 5.37e-82: 297: 17.24
+	Hs
		724697 MYH9_HUMAN (50-565): 3.03e-17: 90.2: 7.20		PK3CA_HUMAN (2097-2701): 5.37e-82: 297: 17.24