Interactor 1: SKI (P12755)
Ski oncogene (Proto-oncogene c-Ski)
Gene: SKI
Interactor 2: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17469184, 12874272, 12857746, 12732634, 11306568, 10575014, 12426322, 17283070, 12154125, 25670202, 19032343, 14699069, 14525983, 19875456, 12764135, 19049980 |
| Identification Methods | affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation, coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | MH2~c-SKI_SMAD_bind |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005654 - nucleoplasm and 10 others more... |
| Homologous interactions | 16 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Gg | |
|
|||||||||||
| + | Gg | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Dm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Dm | |
 |
|||||||||||
| + | Dm | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
