Interactor 1: FAS (P12785)
Fatty acid synthase (EC 2.3.1.85) (Type I FAS) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]
Gene: Fasn

Interactor 2: FAS (P12785)
Fatty acid synthase (EC 2.3.1.85) (Type I FAS) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]
Gene: Fasn

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.911

The method score is based on:

Property Details
Experiments 19151726, 9047334, 11248039, 10206962, 15711565
Identification Methods 3D electron microscopy, molecular sieving, biochemical, two hybrid, cross-linking study, electron microscopy
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Acyl_transf_1~Acyl_transf_1, Acyl_transf_1~KAsynt_C_assoc, Acyl_transf_1~PP-binding, ADH_zinc_N_2~ADH_zinc_N_2, ADH_zinc_N_2~KR, KAsynt_C_assoc~KAsynt_C_assoc, KAsynt_C_assoc~ketoacyl-synt, KAsynt_C_assoc~Ketoacyl-synt_C, ketoacyl-synt~ketoacyl-synt, Ketoacyl-synt_C~ketoacyl-synt, PP-binding~ketoacyl-synt, Ketoacyl-synt_C~Ketoacyl-synt_C, KR~KR, Methyltransf_12~Methyltransf_12, PP-binding~PP-binding, PP-binding~Thioesterase, Thioesterase~Thioesterase
Common GO terms GO:0002068 - glandular epithelial cell development
GO:0004312 - fatty acid synthase activity
GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity
GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity
GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity
and 25 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 2505
Rn

1 2505
+ Hs
+ Ss
+ Bs
+ Ec
+ Mt
+ Ec
+ Sc
+ Mt
+ Pa
+ Sp
+ Hs
+ Hs
+ Hs
+ At
+ Sp
+ Bs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024