HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 25416956, 11470434, 11423549
Identification Methods two hybrid, x-ray crystallography, two hybrid array
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CH~CH, CH~EFhand_Ca_insen, CH~Spectrin, EF-hand_6~EF-hand_6, EFhand_Ca_insen~EFhand_Ca_insen, EFhand_Ca_insen~Spectrin, Spectrin~Spectrin
Common GO terms GO:0001725 - stress fiber
GO:0001726 - ruffle
GO:0003725 - double-stranded RNA binding
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
and 32 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 892
Hs

1 892
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+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024