HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 2843
+	Hs
		164568 SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Hs
		626099 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Hs
		521586 ACTN1_HUMAN (1-892): 0: 697: 100.00		TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55
+	Hs
		521599 ACTN1_HUMAN (1-892): 0: 697: 100.00		CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79
+	Hs
		211629 ACTN4_HUMAN (11-892): 0: 642: 86.74		TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55
+	Hs
		993278 ACTN3_HUMAN (18-892): 0: 642: 78.51		TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55
+	Hs
		725681 ACTN2_HUMAN (10-892): 0: 640: 80.29		TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55
+	Hs
		963451 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		SRRM2_HUMAN (943-2827): 1.37e-30: 135: 8.96
+	Hs
		963398 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79
+	Hs
		963358 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		MICA3_HUMAN (1200-1800): 2.91e-09: 65.2: 13.62