HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	25796446, 31501420, 38280479
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005911 - cell-cell junction GO:0030054 - cell junction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 504
+	Hs
		521619 ACTN1_HUMAN (1-892): 0: 697: 100.00		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		521598 ACTN1_HUMAN (1-892): 0: 697: 100.00		MAGI1_HUMAN (69-305): 1.87e-39: 155: 18.32
+	Hs
		211645 ACTN4_HUMAN (11-892): 0: 642: 86.74		MAGI1_HUMAN (69-305): 1.87e-39: 155: 18.32
+	Hs
		963426 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		164579 SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		808520 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Dm
		1182589 Q7KV70_DROME (369-731): 5.99e-13: 75.5: 14.95		KIBRA_DROME (169-320): 3.18e-32: 133: 28.29