Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: TITIN (Q8WZ42)
Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)
Gene: TTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.867

The method score is based on:

Property Details
Experiments 11305911, 9501083, 11101506
Identification Methods pull down, two hybrid, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CH~fn3, EF-hand_6~Pkinase, EFhand_Ca_insen~Titin_Z
Common GO terms GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005829 - cytosol
GO:0030018 - Z disc
GO:0051015 - actin filament binding
and 1 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 892
Hs

1 34350
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Ce
+ Ce
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024