HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 1164
+	Mm
		1186645 ACTN1_MOUSE (1-892): 0: 694: 99.22		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		725682 ACTN2_HUMAN (10-892): 0: 640: 80.29		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		521484 ACTN1_HUMAN (1-892): 0: 697: 100.00		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		148339 ACTN1_HUMAN (1-892): 0: 697: 100.00		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		211632 ACTN4_HUMAN (11-892): 0: 642: 86.74		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		211515 ACTN4_HUMAN (11-892): 0: 642: 86.74		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		148171 ACTN4_HUMAN (11-892): 0: 642: 86.74		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		148722 ACTN3_HUMAN (18-892): 0: 642: 78.51		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		148463 ACTN2_HUMAN (10-892): 0: 640: 80.29		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		963324 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		164647 SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		164575 SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		963381 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		148142 SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		724781 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		148690 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		148330 SPTB1_HUMAN (235-847): 3.12e-09: 63.1: 10.29		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		149277 SPTN4_HUMAN (173-588): 8.58e-09: 62: 10.82		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Dm
		1182587 Q7KV70_DROME (369-731): 5.99e-13: 75.5: 14.95		Q9VCC9_DROME (835-1160): 2.53e-09: 63.7: 9.76