HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: MYOZ1 (Q9NP98)
Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ)
Gene: MYOZ1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	16189514, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Calsarcin~Spectrin
Common GO terms	GO:0030018 - Z disc GO:0031143 - pseudopodium
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 299
+	Hs
		521621 ACTN1_HUMAN (1-892): 0: 697: 100.00		MYOZ2_HUMAN (6-282): 3.08e-122: 352: 34.30
+	Hs
		211668 ACTN4_HUMAN (11-892): 0: 642: 86.74		MYOZ1_HUMAN (1-299): 3.74e-140: 398: 100.00
+	Hs
		993297 ACTN3_HUMAN (18-892): 0: 642: 78.51		MYOZ1_HUMAN (1-299): 3.74e-140: 398: 100.00
+	Hs
		725701 ACTN2_HUMAN (10-892): 0: 640: 80.29		MYOZ1_HUMAN (1-299): 3.74e-140: 398: 100.00
+	Hs
		211669 ACTN4_HUMAN (11-892): 0: 642: 86.74		MYOZ2_HUMAN (6-282): 3.08e-122: 352: 34.30
+	Hs
		725702 ACTN2_HUMAN (10-892): 0: 640: 80.29		MYOZ2_HUMAN (6-282): 3.08e-122: 352: 34.30