HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: MYOZ2 (Q9NPC6)
Myozenin-2 (Calsarcin-1) (FATZ-related protein 2)
Gene: MYOZ2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	25910212, 25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Calsarcin~Spectrin
Common GO terms	GO:0030018 - Z disc
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 264
+	Hs
		211669 ACTN4_HUMAN (11-892): 0: 642: 86.74		MYOZ2_HUMAN (1-264): 2.9e-158: 441: 100.00
+	Hs
		725702 ACTN2_HUMAN (10-892): 0: 640: 80.29		MYOZ2_HUMAN (1-264): 2.9e-158: 441: 100.00
+	Hs
		521620 ACTN1_HUMAN (1-892): 0: 697: 100.00		MYOZ1_HUMAN (9-72): 3.89e-25: 102: 48.44
+	Hs
		211668 ACTN4_HUMAN (11-892): 0: 642: 86.74		MYOZ1_HUMAN (9-72): 3.89e-25: 102: 48.44
+	Hs
		993297 ACTN3_HUMAN (18-892): 0: 642: 78.51		MYOZ1_HUMAN (9-72): 3.89e-25: 102: 48.44
+	Hs
		725701 ACTN2_HUMAN (10-892): 0: 640: 80.29		MYOZ1_HUMAN (9-72): 3.89e-25: 102: 48.44