HitPredict

Interactor 1: CADH1 (P12830)
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Gene: CDH1

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25468996
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016328 - lateral plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 882 Hs			1 1342
+	Hs
		383569 CADH1_HUMAN (1-882): 0: 836: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337849 CADH1_HUMAN (1-882): 0: 836: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Cl
		94520 CADH1_CANLF (1-882): 0: 804: 81.74		ERBB2_CANLF (10-1222): 0: 1067: 39.36
+	Hs
		383600 CADH2_HUMAN (28-881): 0: 769: 45.86		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337911 CADH2_HUMAN (28-881): 0: 769: 45.86		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338302 DSC2_HUMAN (33-874): 0: 652: 27.88		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		339197 PCDBB_HUMAN (432-868): 1.56e-70: 251: 15.28		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338014 CADH5_HUMAN (30-511): 8.2e-52: 196: 20.91		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		521744 CADH1_HUMAN (1-882): 0: 836: 100.00		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		434134 CADH2_HUMAN (28-881): 0: 769: 45.86		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		435531 CADH2_HUMAN (28-881): 0: 769: 45.86		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		580213 CADH2_HUMAN (28-881): 0: 769: 45.86		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		435534 CADH3_HUMAN (3-882): 0: 716: 53.06		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		435643 DSC3_HUMAN (2-874): 0: 655: 27.92		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		665215 DSC2_HUMAN (33-874): 0: 652: 27.88		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		872632 DSC2_HUMAN (33-874): 0: 652: 27.88		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		521882 CADH1_HUMAN (1-882): 0: 836: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		411386 DSC3_HUMAN (2-874): 0: 655: 27.92		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Hs
		537741 DSC3_HUMAN (2-874): 0: 655: 27.92		INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51
+	Hs
		434321 PCDGH_HUMAN (383-860): 1.9e-69: 249: 16.27		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15