HitPredict

Interactor 1: PSA1 (P12881)
Proteasome subunit alpha type-1 (PROS-Dm35) (Proteasome 35 kDa subunit)
Gene: Prosalpha6

Interactor 2: PSA2 (P40301)
Proteasome subunit alpha type-2 (PROS-Dm25) (Proteasome 25 kDa subunit)
Gene: Prosalpha2

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0019773 - proteasome core complex, alpha-subunit complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 279 Dm			1 234
+	Dm
		522499 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		PSA5_DROME (1-233): 1.55e-97: 286: 30.71
+	Ce
		218159 PSA1_CAEEL (1-240): 8.69e-103: 301: 49.17		PSA2_CAEEL (4-233): 3.6e-99: 289: 60.35
+	Hs
		637325 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38
+	Ss
		94704 F2Z5L7_PIG (1-269): 8.96e-103: 302: 52.42		F2Z5K2_PIG (1-233): 1.45e-98: 288: 31.38
+	Dm
		611647 PSA71_DROME (4-236): 4.09e-102: 299: 30.93		PSA5_DROME (1-233): 1.55e-97: 286: 30.71
+	Hs
		637316 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11
+	Dm
		611631 PSA71_DROME (4-236): 4.09e-102: 299: 30.93		PSA2_DROME (1-234): 2.1e-95: 280: 100.00
+	Hs
		637315 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA1_HUMAN (1-233): 5.72e-92: 272: 30.67
+	Dm
		771318 Q9VK14_DROME (1-268): 1.62e-99: 294: 58.48		PSA2_DROME (1-234): 2.1e-95: 280: 100.00
+	Ss
		94582 F2Z5L7_PIG (1-269): 8.96e-103: 302: 52.42		F1SBA5_PIG (4-227): 5.5e-92: 272: 38.60
+	Hs
		637376 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA6_HUMAN (3-233): 6.35e-91: 269: 32.49
+	Hs
		156223 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA7_HUMAN (6-231): 9.41e-91: 268: 36.52
+	Hs
		637631 PSA5_HUMAN (1-239): 7.88e-95: 280: 30.08		PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11
+	Hs
		156230 PSA5_HUMAN (1-239): 7.88e-95: 280: 30.08		PSA7_HUMAN (6-231): 9.41e-91: 268: 36.52
+	Dm
		522478 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		PSA71_DROME (3-230): 2.89e-44: 150: 36.48
+	Hs
		637494 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSMA8_HUMAN (5-216): 1.1e-47: 159: 40.27
+	Hs
		637318 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA4_HUMAN (3-217): 3.05e-44: 150: 39.64
+	Hs
		638067 PSA5_HUMAN (1-239): 7.88e-95: 280: 30.08		PSA4_HUMAN (3-217): 3.05e-44: 150: 39.64