HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: PECA1 (P16284)
Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)
Gene: PECAM1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	12775720, 10858437, 9162084, 10801826
Identification Methods	affinity chromatography technology, pull down, protein kinase assay
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0045121 - membrane raft GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation GO:0070062 - extracellular exosome and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 536 Hs			1 738
+	Hs
		433242 YES_HUMAN (1-536): 0: 604: 73.85		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		411985 FYN_HUMAN (1-536): 0: 598: 68.39		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		442774 HCK_HUMAN (1-531): 0: 569: 55.22		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		411584 LCK_HUMAN (75-534): 0: 552: 58.48		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		433561 LYN_HUMAN (1-531): 0: 532: 52.44		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		557441 ABL2_HUMAN (11-536): 3.03e-170: 514: 39.03		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		557440 CSK_HUMAN (84-525): 2.44e-172: 496: 39.16		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		434019 LYN_HUMAN (1-531): 0: 532: 52.44		ROBO2_HUMAN (11-737): 1.39e-82: 288: 12.20
+	Hs
		297881 FYN_HUMAN (1-536): 0: 598: 68.39		NFASC_HUMAN (292-736): 1.17e-37: 153: 12.71
+	Hs
		433804 LYN_HUMAN (1-531): 0: 532: 52.44		SDK2_HUMAN (247-738): 8.87e-51: 194: 12.69
+	Mm
		639452 LYN_MOUSE (1-531): 0: 535: 52.26		FCRL5_MOUSE (230-631): 2.04e-45: 173: 17.99
+	Hs
		433569 LYN_HUMAN (1-531): 0: 532: 52.44		CD22_HUMAN (282-633): 8.62e-41: 162: 15.93
+	Hs
		433249 YES_HUMAN (1-536): 0: 604: 73.85		VCAM1_HUMAN (28-407): 7.14e-17: 86.9: 19.75
+	Hs
		434111 LYN_HUMAN (1-531): 0: 532: 52.44		ROBO1_HUMAN (405-725): 5.45e-33: 139: 11.87
+	Hs
		297880 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		NFASC_HUMAN (292-736): 1.17e-37: 153: 12.71
+	Hs
		433742 LYN_HUMAN (1-531): 0: 532: 52.44		PTK7_HUMAN (8-235): 3.28e-27: 120: 12.45
+	Hs
		255429 LCK_HUMAN (75-534): 0: 552: 58.48		OBSL1_HUMAN (72-603): 1.4e-14: 80.3: 15.01