HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 25814554, 23242524, 11119718, 8816475, 11104793, 11980671, 10085298, 37039823, 12615911, 26264872, 12387730, 15987550, 12558988, 9822703, 21855630, 32814053, 16966330, unassigned1126, 17525734, 21034468 and 2 others

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Identification Methods two hybrid, affinity chromatography technology, enzymatic study, pull down, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation, two hybrid array, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_M~PK_Tyr_Ser-Thr, FERM_N_2~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005178 - integrin binding
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
and 19 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 536
Hs

1 1052
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Last updated: 15 Jul 2024