HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.761

Property	Details
Experiments	1545818, 10467411, 22745667, 9038356, 10635328, 7537265, 16169070, 11960376, 8766817, 15190072, 18606683, 1374686
Identification Methods	pull down, affinity chromatography technology, unspecified method, fluorescent resonance energy transfer, enzymatic study, two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007283 - spermatogenesis GO:0042169 - SH2 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 536 Hs			1 443
+	Mm
		403437 SRC_MOUSE (1-536): 0: 650: 98.13		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Mm
		980964 YES_MOUSE (1-536): 0: 598: 73.99		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Mm
		763394 FYN_MOUSE (1-536): 0: 597: 68.58		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		433330 YES_HUMAN (1-536): 0: 604: 73.85		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		412149 FYN_HUMAN (1-536): 0: 598: 68.39		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		454827 FGR_HUMAN (1-535): 0: 583: 65.99		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		442815 HCK_HUMAN (1-531): 0: 569: 55.22		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		411689 LCK_HUMAN (75-534): 0: 552: 58.48		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		639447 LYN_MOUSE (1-531): 0: 535: 52.26		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		433719 LYN_HUMAN (1-531): 0: 532: 52.44		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		789110 FRK_HUMAN (58-528): 3.73e-178: 512: 48.57		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		782780 CSK_HUMAN (84-525): 2.44e-172: 496: 39.16		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991737 ITK_HUMAN (54-525): 1.53e-160: 472: 34.23		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		763412 FYN_MOUSE (1-536): 0: 597: 68.58		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65
+	Hs
		986367 BTK_HUMAN (43-527): 1.18e-154: 458: 34.35		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991758 PTK6_HUMAN (81-529): 3.9e-155: 452: 43.83		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		433822 LYN_HUMAN (1-531): 0: 532: 52.44		KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62
+	Dm
		337713 SRC64_DROME (56-535): 7.2e-178: 514: 51.43		Q9W255_DROME (59-398): 6.04e-96: 295: 32.35
+	Hs
		789069 ABL2_HUMAN (11-536): 3.03e-170: 514: 39.03		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33
+	Hs
		337484 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33