HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15929943
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 536 Hs			1 533
+	Hs
		412165 FYN_HUMAN (1-536): 0: 598: 68.39		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		763395 FYN_MOUSE (1-536): 0: 597: 68.58		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		442821 HCK_HUMAN (1-531): 0: 569: 55.22		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		411700 LCK_HUMAN (75-534): 0: 552: 58.48		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		433736 LYN_HUMAN (1-531): 0: 532: 52.44		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		523025 SRC_HUMAN (1-536): 0: 651: 100.00		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Mm
		763411 FYN_MOUSE (1-536): 0: 597: 68.58		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		522749 SRC_HUMAN (1-536): 0: 651: 100.00		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Mm
		536209 FGR_MOUSE (1-535): 0: 577: 64.55		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Mm
		639462 LYN_MOUSE (1-531): 0: 535: 52.26		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		433917 LYN_HUMAN (1-531): 0: 532: 52.44		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		412433 FYN_HUMAN (1-536): 0: 598: 68.39		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90
+	Hs
		203198 LCK_HUMAN (75-534): 0: 552: 58.48		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		297808 LYN_HUMAN (1-531): 0: 532: 52.44		K0754_HUMAN (18-469): 5.29e-28: 121: 11.97
+	Hs
		411582 LCK_HUMAN (75-534): 0: 552: 58.48		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		782795 CSK_HUMAN (84-525): 2.44e-172: 496: 39.16		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		782797 CSK_HUMAN (84-525): 2.44e-172: 496: 39.16		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		433560 LYN_HUMAN (1-531): 0: 532: 52.44		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		782828 CSK_HUMAN (84-525): 2.44e-172: 496: 39.16		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		337335 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92