HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: PELP1 (Q8IZL8)
Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)
Gene: PELP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	15466214, 14963108
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 536 Hs			1 1130
+	Rn
		1122684 SRC_RAT (1-536): 0: 644: 97.95		PELP1_RAT (1-1130): 0: 668: 81.44
+	Hs
		523092 SRC_HUMAN (1-536): 0: 651: 100.00		CBP_HUMAN (631-1010): 2.14e-28: 126: 16.87
+	Hs
		522749 SRC_HUMAN (1-536): 0: 651: 100.00		MUC1_HUMAN (443-1092): 6.43e-28: 124: 11.79
+	Hs
		64077 SRC_HUMAN (1-536): 0: 651: 100.00		L37A2_HUMAN (602-1129): 5.6e-12: 72.8: 12.80
+	Hs
		522942 SRC_HUMAN (1-536): 0: 651: 100.00		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17
+	Hs
		442866 HCK_HUMAN (1-531): 0: 569: 55.22		CBP_HUMAN (631-1010): 2.14e-28: 126: 16.87
+	Hs
		411582 LCK_HUMAN (75-534): 0: 552: 58.48		MUC1_HUMAN (443-1092): 6.43e-28: 124: 11.79
+	Hs
		411823 LCK_HUMAN (75-534): 0: 552: 58.48		ASPP1_HUMAN (617-1076): 6.49e-23: 108: 15.50
+	Hs
		433930 LYN_HUMAN (1-531): 0: 532: 52.44		CBP_HUMAN (631-1010): 2.14e-28: 126: 16.87
+	Hs
		433560 LYN_HUMAN (1-531): 0: 532: 52.44		MUC1_HUMAN (443-1092): 6.43e-28: 124: 11.79
+	Hs
		433948 LYN_HUMAN (1-531): 0: 532: 52.44		ASPP1_HUMAN (617-1076): 6.49e-23: 108: 15.50
+	Hs
		337335 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		MUC1_HUMAN (443-1092): 6.43e-28: 124: 11.79
+	Hs
		411694 LCK_HUMAN (75-534): 0: 552: 58.48		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17
+	Hs
		203198 LCK_HUMAN (75-534): 0: 552: 58.48		SYNJ1_HUMAN (406-844): 2.09e-10: 67.4: 12.61
+	Mm
		101424 LYN_MOUSE (1-531): 0: 535: 52.26		F8VPR5_MOUSE (679-1121): 6.98e-14: 78.9: 11.49
+	Hs
		297808 LYN_HUMAN (1-531): 0: 532: 52.44		K0754_HUMAN (443-751): 1.25e-14: 81.6: 13.97
+	Hs
		996554 ITK_HUMAN (54-525): 1.53e-160: 472: 34.23		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17