HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: HCN2 (Q9UL51)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2)
Gene: HCN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	16079136, 17474147
Identification Methods	affinity chromatography technology, peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 536 Hs			1 889
+	Hs
		412401 FYN_HUMAN (1-536): 0: 598: 68.39		HCN2_HUMAN (1-889): 0: 693: 100.00
+	Mm
		292104 SRC_MOUSE (1-536): 0: 650: 98.13		HCN2_MOUSE (1-889): 0: 623: 88.23
+	Hs
		239747 SRC_HUMAN (1-536): 0: 651: 100.00		HCN1_HUMAN (67-877): 0: 565: 61.42
+	Hs
		337588 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		HCN2_HUMAN (1-889): 0: 693: 100.00
+	Hs
		239707 FYN_HUMAN (1-536): 0: 598: 68.39		HCN1_HUMAN (67-877): 0: 565: 61.42
+	Hs
		412422 FYN_HUMAN (1-536): 0: 598: 68.39		HCN4_HUMAN (9-875): 2.13e-168: 523: 62.29
+	Hs
		337604 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		HCN4_HUMAN (9-875): 2.13e-168: 523: 62.29
+	Hs
		239955 BTK_HUMAN (43-527): 1.18e-154: 458: 34.35		HCN1_HUMAN (67-877): 0: 565: 61.42