HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: RFA2 (P15927)
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
Gene: RPA2

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	10064605, 24981860, 37827155, 24332808
Identification Methods	affinity chromatography technology, proximity labelling technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0000781 - chromosome, telomeric region GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0042162 - telomeric DNA binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 270
+	Hs
		523714 XRCC6_HUMAN (1-609): 0: 666: 100.00		RFA4_HUMAN (1-268): 6.87e-96: 283: 45.56
+	Hs
		524782 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00
+	Dm
		1095495 KU70_DROME (6-605): 1.24e-155: 462: 22.50		Q9VIH1_DROME (23-267): 4.52e-79: 240: 30.08
+	Dm
		1337254 Q9I7M8_DROME (33-537): 8.43e-105: 333: 15.47		Q9VIH1_DROME (23-267): 4.52e-79: 240: 30.08
+	Sc
		644775 KU80_YEAST (36-591): 1.04e-109: 344: 15.33		RFA2_YEAST (4-264): 9.48e-71: 220: 25.61