HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	30585729, 24981860, 37827155, 24332808
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0000781 - chromosome, telomeric region GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 616
+	Hs
		524800 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Sp
		293301 KU70_SCHPO (19-609): 1.01e-168: 495: 27.04		RFA1_SCHPO (1-614): 0: 617: 37.26
+	Dm
		1095478 KU70_DROME (6-605): 1.24e-155: 462: 22.50		RFA1_DROME (1-614): 0: 619: 41.00
+	Dm
		1097974 Q9I7M8_DROME (33-537): 8.43e-105: 333: 15.47		RFA1_DROME (1-614): 0: 619: 41.00
+	Sc
		607336 KU80_YEAST (36-591): 1.04e-109: 344: 15.33		RFA1_YEAST (4-615): 0: 596: 31.69