HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: DNLI3 (P49916)
DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)
Gene: LIG3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.911

Property	Details
Experiments	28514442, 30585729, 33961781, 12897160
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	DNA_ligase_A_C~Ku_N, DNA_ligase_A_N~Ku_N
Common GO terms	GO:0003677 - DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006266 - DNA ligation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 1009
+	Hs
		524839 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		DNLI3_HUMAN (1-1009): 0: 1373: 100.00
+	Hs
		523597 XRCC6_HUMAN (1-609): 0: 666: 100.00		DNLI4_HUMAN (257-935): 0: 673: 21.58
+	Dm
		1095502 KU70_DROME (6-605): 1.24e-155: 462: 22.50		Q9VYA5_DROME (257-956): 0: 635: 19.95
+	Hs
		524840 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		DNLI4_HUMAN (257-935): 0: 673: 21.58
+	Dm
		1337258 Q9I7M8_DROME (33-537): 8.43e-105: 333: 15.47		Q9VYA5_DROME (257-956): 0: 635: 19.95
+	Sc
		979558 KU80_YEAST (36-591): 1.04e-109: 344: 15.33		DNLI4_YEAST (284-934): 9.79e-157: 489: 18.73