HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: SIR6 (Q8N6T7)
NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
Gene: SIRT6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20157594
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 355
+	Hs
		523930 XRCC6_HUMAN (1-609): 0: 666: 100.00		SIR1_HUMAN (25-336): 3.35e-99: 311: 21.83
+	Hs
		524029 XRCC6_HUMAN (1-609): 0: 666: 100.00		SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61
+	Hs
		524033 XRCC6_HUMAN (1-609): 0: 666: 100.00		SIR3_HUMAN (33-287): 6.34e-90: 276: 27.92
+	Hs
		524984 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00
+	Hs
		525077 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61