HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: KAT2A (Q92830)
Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)
Gene: KAT2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	9488450
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 837
+	Hs
		523914 XRCC6_HUMAN (1-609): 0: 666: 100.00		KAT2B_HUMAN (84-837): 0: 1095: 74.31
+	Hs
		525005 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		KAT2A_HUMAN (75-837): 0: 1159: 100.00
+	Hs
		170234 XRCC6_HUMAN (1-609): 0: 666: 100.00		TIF1A_HUMAN (626-832): 1.23e-44: 176: 22.86
+	Hs
		523701 XRCC6_HUMAN (1-609): 0: 666: 100.00		BPTF_HUMAN (730-830): 2.17e-38: 157: 49.51
+	Hs
		523699 XRCC6_HUMAN (1-609): 0: 666: 100.00		EP300_HUMAN (652-832): 2.03e-37: 154: 19.02
+	Hs
		524066 XRCC6_HUMAN (1-609): 0: 666: 100.00		BAZ2A_HUMAN (647-837): 1.05e-36: 151: 22.51
+	Hs
		243858 XRCC6_HUMAN (1-609): 0: 666: 100.00		BRD4_HUMAN (657-833): 1.8e-30: 131: 21.43
+	Hs
		523873 XRCC6_HUMAN (1-609): 0: 666: 100.00		TAF1L_HUMAN (727-831): 8.11e-12: 71.6: 34.26
+	Hs
		524031 XRCC6_HUMAN (1-609): 0: 666: 100.00		BAZ1A_HUMAN (735-834): 1e-11: 71.2: 30.00
+	Hs
		523519 XRCC6_HUMAN (1-609): 0: 666: 100.00		TAF1_HUMAN (733-831): 8.58e-09: 61.6: 30.30
+	Hs
		170235 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		TIF1A_HUMAN (626-832): 1.23e-44: 176: 22.86
+	Hs
		524894 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		EP300_HUMAN (652-832): 2.03e-37: 154: 19.02
+	Hs
		525104 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		TRI33_HUMAN (630-836): 1.1e-36: 151: 19.74
+	Hs
		243859 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		BRD4_HUMAN (657-833): 1.8e-30: 131: 21.43
+	Hs
		524997 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		PHIP_HUMAN (729-831): 2.23e-15: 83.3: 21.70
+	Hs
		525080 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		BAZ1A_HUMAN (735-834): 1e-11: 71.2: 30.00