HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: RECQ1 (P46063)
ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)
Gene: RECQL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	28186131, 23396353
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003678 - DNA helicase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 649
+	Hs
		524923 XRCC5_HUMAN (1-732): 0: 755: 100.00		WRN_HUMAN (11-642): 8.49e-137: 436: 26.10
+	Hs
		294317 XRCC5_HUMAN (1-732): 0: 755: 100.00		RECQ4_HUMAN (76-453): 5.17e-127: 405: 30.39
+	Hs
		525006 XRCC5_HUMAN (1-732): 0: 755: 100.00		DDX17_HUMAN (8-505): 7.91e-129: 398: 14.54
+	Hs
		523577 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		RECQ1_HUMAN (1-649): 1.14e-156: 467: 100.00
+	Hs
		523746 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		WRN_HUMAN (11-642): 8.49e-137: 436: 26.10
+	Hs
		294316 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		RECQ4_HUMAN (76-453): 5.17e-127: 405: 30.39
+	Hs
		523624 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		BLM_HUMAN (48-617): 4.7e-125: 404: 35.01
+	Hs
		523915 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		DDX17_HUMAN (8-505): 7.91e-129: 398: 14.54
+	Hs
		523506 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		DDX5_HUMAN (9-468): 1.14e-125: 386: 15.97
+	Hs
		523861 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		DDX42_HUMAN (2-458): 4.83e-115: 368: 14.44
+	Hs
		133861 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		DDX3X_HUMAN (16-447): 1.24e-115: 362: 12.66