HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	15377652
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BRCT_2~Ku, BRCT_2~Ku_C
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 2089
+	Hs
		523752 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		524898 XRCC5_HUMAN (1-732): 0: 755: 100.00		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		523704 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		523576 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		523833 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		523903 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		524090 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08
+	Hs
		523956 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		MINT_HUMAN (159-1473): 1.72e-10: 68.9: 10.33