HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15272235, 35031618
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 826
+	Hs
		525036 XRCC5_HUMAN (1-732): 0: 755: 100.00		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		523791 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		525116 XRCC5_HUMAN (1-732): 0: 755: 100.00		NCOA3_HUMAN (1-746): 4.42e-98: 335: 15.31
+	Hs
		523966 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		523535 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06