HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: PAXX (Q9BUH6)
Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein)
Gene: PAXX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.657

Property	Details
Experiments	30017584, 25574025, 31548606
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006303 - double-strand break repair via nonhomologous end joining GO:0006974 - DNA damage response GO:0070419 - nonhomologous end joining complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 204
+	Hs
		523979 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		PAXX_HUMAN (1-204): 9.6e-134: 374: 100.00