HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: TRI33 (Q9UPN9)
E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)
Gene: TRIM33

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36261009
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 1127
+	Hs
		170235 XRCC5_HUMAN (1-732): 0: 755: 100.00		TIF1A_HUMAN (106-1127): 7.13e-146: 467: 44.94
+	Hs
		170234 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		TIF1A_HUMAN (106-1127): 7.13e-146: 467: 44.94
+	Hs
		524906 XRCC5_HUMAN (1-732): 0: 755: 100.00		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20
+	Hs
		523911 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		CBP_HUMAN (517-1061): 4.54e-59: 225: 15.06
+	Hs
		524066 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		BAZ2A_HUMAN (886-1085): 3.19e-44: 177: 26.80
+	Hs
		523718 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		TIF1B_HUMAN (631-1105): 6.36e-25: 114: 18.20