HitPredict

Interactor 1: ESM5 (P13096)
Enhancer of split m5 protein (E(spl)m5)
Gene: E(spl)m5-HLH

Interactor 2: GROU (P16371)
Protein groucho (Enhancer of split m9/10 protein) (E(spl)m9/10)
Gene: gro

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	9371806, 16762837, 8001118, 9524128, 14605208
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0007399 - nervous system development GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 178 Dm			1 730
+	Dm
		525718 ESM7_DROME (11-178): 1.79e-53: 169: 38.17		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		525743 ESM8_DROME (11-178): 6.02e-52: 165: 60.34		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558370 ESMB_DROME (9-178): 3.08e-51: 164: 32.49		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558371 ESMC_DROME (11-178): 3.9e-49: 159: 33.33		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558377 DPN_DROME (6-168): 6.55e-45: 154: 21.67		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558372 ESMD_DROME (6-178): 4.06e-45: 148: 29.35		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558369 ESM3_DROME (10-178): 1.07e-41: 141: 25.11		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		534341 HAIR_DROME (1-166): 1.22e-39: 139: 23.98		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Hs
		980604 HES1_HUMAN (2-137): 2.9e-51: 167: 23.94		TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08
+	Hs
		980671 HEY1_HUMAN (1-173): 3.02e-46: 155: 16.13		TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08
+	Hs
		980651 HES4_HUMAN (2-178): 8.84e-44: 146: 21.68		TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08
+	Hs
		980948 HES6_HUMAN (2-178): 2.71e-41: 140: 17.57		TLE4_HUMAN (1-730): 4.44e-156: 473: 60.87
+	Hs
		980638 HES6_HUMAN (2-178): 2.71e-41: 140: 17.57		TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08
+	Hs
		980686 HES1_HUMAN (2-137): 2.9e-51: 167: 23.94		TLE2_HUMAN (1-730): 8.83e-141: 432: 55.91
+	Hs
		980840 HES6_HUMAN (2-178): 2.71e-41: 140: 17.57		TLE3_HUMAN (1-730): 2.82e-146: 447: 57.27
+	Hs
		62468 HELT_HUMAN (12-176): 8.07e-44: 147: 17.39		TLE5_HUMAN (1-197): 8.88e-84: 265: 49.51
+	Hs
		993550 HES6_HUMAN (2-178): 2.71e-41: 140: 17.57		TLE5_HUMAN (1-197): 8.88e-84: 265: 49.51
+	Hs
		146485 BHE40_HUMAN (4-175): 9.06e-39: 138: 15.71		TLE5_HUMAN (1-197): 8.88e-84: 265: 49.51
+	Rn
		193468 BHE40_RAT (4-177): 6.62e-42: 146: 17.10		GBB2_RAT (646-729): 4.64e-14: 76: 15.29
+	Hs
		146473 BHE40_HUMAN (4-175): 9.06e-39: 138: 15.71		GBB2_HUMAN (646-729): 4.64e-14: 76: 15.29