HitPredict

Interactor 1: ESM7 (P13097)
Enhancer of split m7 protein (E(spl)m7)
Gene: E(spl)m7-HLH

Interactor 2: GROU (P16371)
Protein groucho (Enhancer of split m9/10 protein) (E(spl)m9/10)
Gene: gro

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	16762837, 8001118, 8649374, 9751710, 10433905, 17571073, 9371806, 25694512, 22949507, 15507447
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0007399 - nervous system development GO:0030154 - cell differentiation GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 186 Dm			1 730
+	Dm
		558370 ESMB_DROME (1-186): 7.96e-53: 168: 44.06		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		525743 ESM8_DROME (7-186): 1.08e-51: 165: 40.00		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558371 ESMC_DROME (6-186): 2.48e-51: 165: 47.48		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558377 DPN_DROME (9-181): 1.56e-43: 151: 26.82		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558369 ESM3_DROME (3-186): 1.05e-44: 149: 35.56		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		558372 ESMD_DROME (7-186): 2.42e-45: 149: 38.83		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Dm
		525705 ESM5_DROME (8-186): 3.79e-43: 143: 40.00		GROU_DROME (1-730): 4.17e-172: 513: 100.00
+	Hs
		980671 HEY1_HUMAN (7-180): 5.81e-44: 149: 22.40		TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08
+	Hs
		980604 HES1_HUMAN (3-123): 6.01e-44: 148: 35.43		TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08
+	Hs
		980651 HES4_HUMAN (3-186): 1.01e-41: 141: 27.04		TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08
+	Hs
		980948 HES6_HUMAN (9-186): 6.95e-39: 134: 28.50		TLE4_HUMAN (1-730): 4.44e-156: 473: 60.87
+	Hs
		980638 HES6_HUMAN (9-186): 6.95e-39: 134: 28.50		TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08
+	Mm
		1143960 HES6_MOUSE (9-186): 1.6e-38: 133: 26.44		TLE1_MOUSE (1-730): 2.22e-148: 453: 59.57
+	Hs
		980840 HES6_HUMAN (9-186): 6.95e-39: 134: 28.50		TLE3_HUMAN (1-730): 2.82e-146: 447: 57.27
+	Hs
		980686 HES1_HUMAN (3-123): 6.01e-44: 148: 35.43		TLE2_HUMAN (1-730): 8.83e-141: 432: 55.91
+	Hs
		62468 HELT_HUMAN (7-184): 9.16e-44: 147: 23.68		TLE5_HUMAN (1-197): 8.88e-84: 265: 49.51
+	Hs
		146485 BHE40_HUMAN (6-181): 2.68e-37: 134: 22.44		TLE5_HUMAN (1-197): 8.88e-84: 265: 49.51
+	Hs
		993550 HES6_HUMAN (9-186): 6.95e-39: 134: 28.50		TLE5_HUMAN (1-197): 8.88e-84: 265: 49.51
+	Rn
		193468 BHE40_RAT (6-182): 2e-38: 137: 22.33		GBB2_RAT (646-729): 4.64e-14: 76: 15.29
+	Hs
		146473 BHE40_HUMAN (6-181): 2.68e-37: 134: 22.44		GBB2_HUMAN (646-729): 4.64e-14: 76: 15.29