HitPredict

Interactor 1: CCL4 (P13236)
C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
Gene: CCL4

Interactor 2: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20959807
Identification Methods	protease assay
Interaction Type	cleavage reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 1019
+	Hs
		539773 CL3L1_HUMAN (1-92): 5.95e-38: 123: 58.70		IDE_HUMAN (1-1019): 0: 1084: 100.00
+	Hs
		486219 CCL3_HUMAN (1-92): 6.04e-35: 116: 57.61		IDE_HUMAN (1-1019): 0: 1084: 100.00
+	Hs
		539790 CCL23_HUMAN (1-92): 1.9e-27: 98.1: 33.93		IDE_HUMAN (1-1019): 0: 1084: 100.00
+	Hs
		134740 CCL22_HUMAN (21-91): 1.92e-21: 81.9: 34.72		PREP_HUMAN (91-965): 1.14e-133: 431: 13.57