HitPredict

Interactor 1: CCL4 (P13236)
C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
Gene: CCL4

Interactor 2: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	10498628, 9468473, 9334377, 10477718, 23597562
Identification Methods	experimental interaction detection, biochemical, competition binding, scintillation proximity assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006954 - inflammatory response GO:0006955 - immune response GO:0007186 - G protein-coupled receptor signaling pathway GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 92 Hs			1 352
+	Hs
		561733 CL3L1_HUMAN (1-92): 5.95e-38: 123: 58.70		CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00
+	Hs
		849654 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00
+	Hs
		1305163 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35
+	Hs
		526560 CCL4_HUMAN (1-92): 8.21e-38: 123: 100.00		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Hs
		561728 CL3L1_HUMAN (1-92): 5.95e-38: 123: 58.70		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Mm
		500591 CCL3_MOUSE (1-92): 5.78e-37: 121: 60.87		CCR3_MOUSE (6-352): 1.47e-80: 251: 55.46
+	Hs
		686667 CCL14_HUMAN (1-92): 2.01e-35: 117: 43.01		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Hs
		783833 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		CCR2_HUMAN (2-331): 3.91e-79: 248: 70.91
+	Hs
		486230 CCL3_HUMAN (1-92): 6.04e-35: 116: 57.61		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Mm
		500590 CCL3_MOUSE (1-92): 5.78e-37: 121: 60.87		CCR1_MOUSE (4-352): 2.53e-73: 232: 54.57
+	Hs
		526561 CCL4_HUMAN (1-92): 8.21e-38: 123: 100.00		CXCR5_HUMAN (7-346): 8.85e-70: 224: 26.74
+	Hs
		526564 CCL4_HUMAN (1-92): 8.21e-38: 123: 100.00		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		561732 CL3L1_HUMAN (1-92): 5.95e-38: 123: 58.70		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		849619 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		849616 CCL14_HUMAN (1-92): 2.01e-35: 117: 43.01		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		134356 CCL4_HUMAN (1-92): 8.21e-38: 123: 100.00		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Hs
		134400 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Hs
		134380 CCL14_HUMAN (1-92): 2.01e-35: 117: 43.01		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Hs
		134354 CCL3_HUMAN (1-92): 6.04e-35: 116: 57.61		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Hs
		830629 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		CXCR3_HUMAN (16-308): 2.75e-47: 165: 36.49