HitPredict

Interactor 1: MYF5 (P13349)
Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2)
Gene: MYF5

Interactor 2: ID3 (Q02535)
DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005654 - nucleoplasm GO:0007517 - muscle organ development GO:0046983 - protein dimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 119
+	Hs
		526743 MYF5_HUMAN (1-255): 8.04e-88: 262: 100.00		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		526742 MYF5_HUMAN (1-255): 8.04e-88: 262: 100.00		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Mm
		485938 MYOD1_MOUSE (7-255): 8.65e-56: 183: 43.29		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Hs
		545959 MYOD1_HUMAN (7-255): 1.76e-54: 179: 42.67		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Mm
		485939 MYOD1_MOUSE (7-255): 8.65e-56: 183: 43.29		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Mm
		485951 MYOD1_MOUSE (7-255): 8.65e-56: 183: 43.29		Q6GTZ3_MOUSE (3-100): 6.94e-41: 134: 46.60
+	Hs
		545958 MYOD1_HUMAN (7-255): 1.76e-54: 179: 42.67		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		545945 MYOD1_HUMAN (7-255): 1.76e-54: 179: 42.67		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		546071 MYOG_HUMAN (9-220): 2.93e-44: 150: 38.12		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		524557 LYL1_HUMAN (58-202): 1.84e-21: 92.3: 21.92		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Mm
		589139 TAL1_MOUSE (62-241): 5.84e-31: 118: 22.10		ID1_MOUSE (3-100): 5.07e-42: 137: 46.60
+	Hs
		616610 MYF6_HUMAN (9-227): 3.4e-45: 153: 38.72		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		546072 MYOG_HUMAN (9-220): 2.93e-44: 150: 38.12		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		524547 LYL1_HUMAN (58-202): 1.84e-21: 92.3: 21.92		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		568188 TAL1_HUMAN (62-241): 1.47e-32: 123: 23.20		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		814916 NGN3_HUMAN (23-208): 5.67e-29: 110: 21.16		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		524549 LYL1_HUMAN (58-202): 1.84e-21: 92.3: 21.92		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71