HitPredict

Interactor 1: MYF5 (P13349)
Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2)
Gene: MYF5

Interactor 2: FIGLA (Q6QHK4)
Factor in the germline alpha (FIGalpha) (Class C basic helix-loop-helix protein 8) (bHLHc8) (Folliculogenesis-specific basic helix-loop-helix protein) (Transcription factor FIGa)
Gene: FIGLA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0046983 - protein dimerization activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 219
+	Hs
		545988 MYOD1_HUMAN (7-255): 1.76e-54: 179: 42.67		FIGLA_HUMAN (1-219): 1.11e-70: 216: 100.00
+	Hs
		526750 MYF5_HUMAN (1-255): 8.04e-88: 262: 100.00		SCX_HUMAN (3-171): 1.81e-29: 110: 22.91
+	Hs
		546085 MYOG_HUMAN (9-220): 2.93e-44: 150: 38.12		FIGLA_HUMAN (1-219): 1.11e-70: 216: 100.00
+	Dm
		611973 MYOD_DROME (8-252): 6.38e-55: 181: 37.50		Q9VL05_DROME (53-176): 5.3e-35: 123: 29.03
+	Mm
		485933 MYOD1_MOUSE (7-255): 8.65e-56: 183: 43.29		MYOD1_MOUSE (1-176): 4.62e-30: 114: 17.61
+	Hs
		210855 MYOD1_HUMAN (7-255): 1.76e-54: 179: 42.67		TCF21_HUMAN (20-125): 1.97e-26: 101: 28.97
+	Mm
		603903 TAL1_MOUSE (62-241): 5.84e-31: 118: 22.10		LYL1_MOUSE (11-201): 2.27e-35: 128: 22.28
+	Hs
		524533 TAL1_HUMAN (62-241): 1.47e-32: 123: 23.20		LYL1_HUMAN (3-201): 2.87e-30: 114: 21.39
+	Mm
		1141807 NDF1_MOUSE (4-253): 9.24e-34: 126: 15.73		NDF1_MOUSE (55-183): 3.54e-27: 108: 24.81
+	Hs
		568173 TAL1_HUMAN (62-241): 1.47e-32: 123: 23.20		TAL1_HUMAN (22-136): 5.62e-27: 107: 29.31
+	Mm
		1142071 HAND2_MOUSE (7-144): 2.82e-29: 111: 22.38		HAND2_MOUSE (20-175): 5.32e-30: 112: 22.36
+	Dm
		80872 ATO_DROME (16-139): 4.51e-29: 113: 28.57		DIMM_DROME (5-183): 8.24e-28: 110: 19.13
+	Hs
		899117 HAND2_HUMAN (7-144): 2.82e-29: 111: 22.38		HAND2_HUMAN (20-175): 5.32e-30: 112: 22.36
+	Mm
		603895 TAL1_MOUSE (62-241): 5.84e-31: 118: 22.10		TAL1_MOUSE (22-131): 5.06e-26: 104: 29.73
+	Hs
		568212 TAL1_HUMAN (62-241): 1.47e-32: 123: 23.20		TAL2_HUMAN (64-130): 1.24e-25: 97.9: 32.84
+	Mm
		1142073 HAND2_MOUSE (7-144): 2.82e-29: 111: 22.38		HAND1_MOUSE (47-159): 1.64e-27: 105: 30.09
+	Hs
		1261462 TWST2_HUMAN (30-142): 4.2e-28: 106: 23.89		FER3L_HUMAN (54-130): 6.15e-26: 100: 27.27
+	Hs
		1076849 TWST2_HUMAN (30-142): 4.2e-28: 106: 23.89		TWST1_HUMAN (58-129): 2.8e-24: 97.1: 34.72