HitPredict

Interactor 1: MYF5 (P13349)
Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2)
Gene: MYF5

Interactor 2: SCX (Q7RTU7)
Basic helix-loop-helix transcription factor scleraxis (Class A basic helix-loop-helix protein 41) (bHLHa41) (Class A basic helix-loop-helix protein 48) (bHLHa48)
Gene: SCX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0006357 - regulation of transcription by RNA polymerase II GO:0035914 - skeletal muscle cell differentiation and 1 others more... GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 201
+	Hs
		526739 MYF5_HUMAN (1-255): 8.04e-88: 262: 100.00		TFE2_HUMAN (8-176): 1.02e-29: 116: 17.34
+	Hs
		526745 MYF5_HUMAN (1-255): 8.04e-88: 262: 100.00		HEN2_HUMAN (35-131): 6.47e-23: 91: 37.76
+	Hs
		545932 MYOD1_HUMAN (7-255): 1.76e-54: 179: 42.67		TFE2_HUMAN (8-176): 1.02e-29: 116: 17.34
+	Mm
		485933 MYOD1_MOUSE (7-255): 8.65e-56: 183: 43.29		MYOD1_MOUSE (10-194): 7.89e-29: 111: 19.68
+	Dm
		611973 MYOD_DROME (8-252): 6.38e-55: 181: 37.50		Q9VL05_DROME (64-183): 6.48e-30: 110: 33.33
+	Mm
		485935 MYOD1_MOUSE (7-255): 8.65e-56: 183: 43.29		TFE2_MOUSE (8-176): 2.29e-26: 107: 16.28
+	Hs
		546034 MYOD1_HUMAN (7-255): 1.76e-54: 179: 42.67		HTF4_HUMAN (28-175): 1.13e-26: 108: 20.13
+	Hs
		210855 MYOD1_HUMAN (7-255): 1.76e-54: 179: 42.67		TCF21_HUMAN (28-135): 2.64e-26: 101: 38.89
+	Hs
		551472 MYF6_HUMAN (9-227): 3.4e-45: 153: 38.72		TFE2_HUMAN (8-176): 1.02e-29: 116: 17.34
+	Hs
		546066 MYOG_HUMAN (9-220): 2.93e-44: 150: 38.12		TFE2_HUMAN (8-176): 1.02e-29: 116: 17.34
+	Hs
		616615 MYF6_HUMAN (9-227): 3.4e-45: 153: 38.72		HTF4_HUMAN (28-175): 1.13e-26: 108: 20.13
+	Hs
		546105 MYOG_HUMAN (9-220): 2.93e-44: 150: 38.12		HTF4_HUMAN (28-175): 1.13e-26: 108: 20.13
+	Hs
		546087 MYOG_HUMAN (9-220): 2.93e-44: 150: 38.12		BHA15_HUMAN (6-178): 1.74e-26: 101: 26.67
+	Mm
		1141807 NDF1_MOUSE (4-253): 9.24e-34: 126: 15.73		NDF1_MOUSE (7-182): 3.48e-31: 118: 22.00
+	Hs
		551564 ATOH1_HUMAN (62-245): 2.77e-34: 128: 19.25		TFE2_HUMAN (8-176): 1.02e-29: 116: 17.34
+	Hs
		551521 NDF1_HUMAN (4-253): 3.66e-34: 127: 15.73		TFE2_HUMAN (8-176): 1.02e-29: 116: 17.34
+	Hs
		1271845 ATOH1_HUMAN (62-245): 2.77e-34: 128: 19.25		HTF4_HUMAN (28-175): 1.13e-26: 108: 20.13
+	Hs
		1039378 NDF1_HUMAN (4-253): 3.66e-34: 127: 15.73		HTF4_HUMAN (28-175): 1.13e-26: 108: 20.13
+	Mm
		550207 NDF1_MOUSE (4-253): 9.24e-34: 126: 15.73		TFE2_MOUSE (8-176): 2.29e-26: 107: 16.28
+	Hs
		524533 TAL1_HUMAN (62-241): 1.47e-32: 123: 23.20		LYL1_HUMAN (42-175): 4.55e-26: 102: 30.46