Interactor 1: DPOLA (P13382)
DNA polymerase alpha catalytic subunit A (EC 2.7.7.7) (DNA polymerase I subunit A) (DNA polymerase alpha:primase complex p180 subunit) (DNA polymerase-primase complex p180 subunit) (Pol alpha-primase complex p180 subunit)
Gene: POL1

Interactor 2: PRI2 (P20457)
DNA primase large subunit (DNA polymerase alpha:primase complex p58 subunit) (DNA polymerase-primase complex p58 subunit) (Pol alpha-primase complex p58 subunit) (DNA primase 58 kDa subunit)
Gene: PRI2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.916

The method score is based on:

Property Details
Experiments 16429126, 37344454, 37968396, 21715379, 22593576
Identification Methods affinity chromatography technology, biochemical, x-ray crystallography, pull down, tandem affinity purification
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DNA_pol_B~DNA_primase_lrg, DNA_primase_lrg~zf-DNA_Pol
Common GO terms GO:0005658 - alpha DNA polymerase:primase complex
GO:0006260 - DNA replication
GO:0006270 - DNA replication initiation
GO:0006302 - double-strand break repair
GO:0046872 - metal ion binding
and 1 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1468
Sc

1 528
+ Hs
+ Sp
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024