HitPredict

Interactor 1: TDGF1 (P13385)
Protein Cripto (Cripto, EGF-CFC family member) (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) (Teratocarcinoma-derived growth factor 1)
Gene: CRIPTO

Interactor 2: BMP6 (P22004)
Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)
Gene: BMP6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28126904
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0008083 - growth factor activity GO:0008284 - positive regulation of cell population proliferation GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 188 Hs			1 513
+	Hs
		526872 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		BMP7_HUMAN (64-513): 4.73e-152: 442: 59.33
+	Hs
		520088 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		BMP4_HUMAN (159-512): 1.06e-106: 326: 33.42
+	Hs
		526914 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		NODAL_HUMAN (172-512): 4.82e-75: 242: 22.64
+	Hs
		451816 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		INHBB_HUMAN (148-512): 1.51e-73: 240: 21.69
+	Hs
		526921 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		GDF3_HUMAN (152-512): 5.22e-71: 232: 26.58
+	Hs
		233921 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		GDF9_HUMAN (147-512): 3.92e-64: 217: 18.45
+	Hs
		312844 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		GDF11_HUMAN (298-512): 1.19e-53: 188: 28.37
+	Hs
		474736 CFC1_HUMAN (52-150): 3.46e-39: 135: 41.41		BMP8A_HUMAN (68-513): 1.22e-122: 366: 45.29
+	Hs
		474690 CFC1_HUMAN (52-150): 3.46e-39: 135: 41.41		BMP4_HUMAN (159-512): 1.06e-106: 326: 33.42
+	Mm
		792909 CFC1_MOUSE (82-150): 1.88e-39: 135: 50.73		NODAL_MOUSE (172-512): 1.02e-71: 234: 24.58