HitPredict

Interactor 1: RB (P13405)
Retinoblastoma-associated protein (p110-RB1) (pRb) (Rb) (pp105)
Gene: Rb1

Interactor 2: E2F4 (Q8R0K9)
Transcription factor E2F4 (E2F-4)
Gene: E2F4

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	20946988
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	E2F_CC-MB~Rb_C
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 921 Mm			1 410
+	Hs
		414299 RB_HUMAN (1-921): 0: 1290: 89.87		E2F4_HUMAN (1-410): 1.02e-175: 498: 91.79
+	Hs
		414295 RB_HUMAN (1-921): 0: 1290: 89.87		E2F5_HUMAN (16-409): 2.76e-113: 336: 52.15
+	Hs
		135199 RB_HUMAN (1-921): 0: 1290: 89.87		E2F3_HUMAN (5-260): 2.4e-85: 269: 37.21
+	Mm
		192503 RB_MOUSE (18-921): 0: 1290: 100.00		E2F3_MOUSE (5-260): 2.5e-84: 266: 37.84
+	Hs
		414284 RB_HUMAN (1-921): 0: 1290: 89.87		E2F2_HUMAN (4-251): 7.32e-80: 254: 44.40
+	Mm
		527140 RB_MOUSE (18-921): 0: 1290: 100.00		E2F2_MOUSE (4-251): 1.79e-79: 253: 43.20
+	Rn
		140344 RB_RAT (1-921): 0: 1298: 95.22		E2F1_RAT (10-252): 2.31e-68: 224: 35.80
+	Hs
		265585 RB_HUMAN (1-921): 0: 1290: 89.87		E2F6_HUMAN (17-246): 1.18e-70: 225: 33.62
+	Mm
		527156 RB_MOUSE (18-921): 0: 1290: 100.00		E2F1_MOUSE (10-259): 3.42e-67: 221: 35.47
+	Hs
		414250 RB_HUMAN (1-921): 0: 1290: 89.87		E2F1_HUMAN (10-252): 6.79e-66: 218: 35.39
+	At
		1324895 RBR1_ARATH (13-803): 0: 626: 22.07		E2FA_ARATH (3-279): 1.12e-95: 296: 36.40
+	At
		1325150 RBR1_ARATH (13-803): 0: 626: 22.07		E2FB_ARATH (4-251): 8.22e-78: 250: 41.04
+	Dm
		1097882 RBF_DROME (18-859): 0: 681: 21.82		E2F1_DROME (13-221): 9.52e-52: 187: 37.09
+	At
		1325146 RBR1_ARATH (13-803): 0: 626: 22.07		E2FC_ARATH (1-226): 7.17e-73: 235: 41.30
+	Dm
		284513 RBF_DROME (18-859): 0: 681: 21.82		E2F2_DROME (5-210): 6.79e-48: 169: 31.82
+	Mm
		1145491 RBL1_MOUSE (587-868): 3.61e-88: 305: 29.85		E2F4_MOUSE (1-410): 5.34e-179: 506: 100.00
+	Ce
		106296 LIN35_CAEEL (48-776): 4.4e-133: 425: 18.91		G5EF11_CAEEL (12-227): 1.43e-61: 203: 38.33
+	Hs
		135214 RBL1_HUMAN (587-868): 4.17e-83: 291: 28.27		E2F3_HUMAN (5-260): 2.4e-85: 269: 37.21
+	Dm
		284539 Q9NIS1_DROME (45-757): 1.02e-97: 326: 17.04		E2F2_DROME (5-210): 6.79e-48: 169: 31.82
+	Dm
		284545 Q9VF04_DROME (45-757): 2.07e-97: 325: 16.91		E2F2_DROME (5-210): 6.79e-48: 169: 31.82