HitPredict

Interactor 1: METK1 (P13444)
S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III)
Gene: Mat1a

Interactor 2: METK1 (P13444)
S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III)
Gene: Mat1a

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 1.00 0.757

The method score is based on:

Property Details
Experiments 27548429, 9202427
Identification Methods two hybrid, reverse phase chromatography
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains S-AdoMet_synt_C~S-AdoMet_synt_C, S-AdoMet_synt_C~S-AdoMet_synt_M, S-AdoMet_synt_C~S-AdoMet_synt_N, S-AdoMet_synt_M~S-AdoMet_synt_M, S-AdoMet_synt_M~S-AdoMet_synt_N, S-AdoMet_synt_N~S-AdoMet_synt_N
Common GO terms GO:0000287 - magnesium ion binding
GO:0004478 - methionine adenosyltransferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006556 - S-adenosylmethionine biosynthetic process
and 8 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 397
Rn

1 397
+ Hs
+ Hs
+ Hs
+ Sc
+ Sc
+ Sc
+ Zm
+ Sp
+ Ce
+ Ce
+ Ce
+ Ce
+ Dm
+ Ec
+ Pf

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Last updated: 15 Jul 2024