HitPredict

Interactor 1: LAMP2 (P13473)
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)
Gene: LAMP2

Interactor 2: PKHM1 (Q9Y4G2)
Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)
Gene: PLEKHM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 33452816
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005764 - lysosome GO:0031902 - late endosome membrane GO:0043231 - intracellular membrane-bounded organelle GO:0044754 - autolysosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 1056
+	Hs
		507332 LAMP1_HUMAN (26-410): 3.76e-155: 446: 34.43		PKHM1_HUMAN (1-1056): 0: 1398: 100.00
+	Hs
		527560 LAMP2_HUMAN (1-410): 0: 557: 100.00		PKHM3_HUMAN (406-1055): 0: 811: 28.33
+	Hs
		1173326 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		PKHM3_HUMAN (406-1055): 0: 811: 28.33
+	Hs
		527563 LAMP2_HUMAN (1-410): 0: 557: 100.00		RUFY3_HUMAN (15-334): 1.28e-80: 272: 18.90
+	Hs
		527754 LAMP2_HUMAN (1-410): 0: 557: 100.00		FYCO1_HUMAN (12-397): 5.7e-66: 245: 12.19
+	Hs
		527737 LAMP2_HUMAN (1-410): 0: 557: 100.00		RUFY1_HUMAN (13-506): 8.59e-67: 240: 18.15
+	Hs
		527658 LAMP2_HUMAN (1-410): 0: 557: 100.00		SNX29_HUMAN (7-492): 8.21e-57: 213: 17.42
+	Hs
		527677 LAMP2_HUMAN (1-410): 0: 557: 100.00		RUBIC_HUMAN (8-435): 4.95e-09: 62.6: 16.05
+	Hs
		1183401 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		RUFY3_HUMAN (15-334): 1.28e-80: 272: 18.90
+	Hs
		1256647 LAMP3_HUMAN (155-410): 7.26e-75: 240: 25.95		SNX29_HUMAN (7-492): 8.21e-57: 213: 17.42