HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: CCR1 (P32246)
C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
Gene: CCR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.968

The method score is based on:

Property Details
Experiments 11449371, 11116158, 8530354, 9115216, 7622448, 9336350, 10910894, 7545673, 28381538
Identification Methods pull down, experimental interaction detection, biochemical, competition binding, fluorescence-activated cell sorting
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~IL8
Common GO terms GO:0002407 - dendritic cell chemotaxis
GO:0004435 - phosphatidylinositol phospholipase C activity
GO:0005737 - cytoplasm
GO:0006816 - calcium ion transport
GO:0006874 - intracellular calcium ion homeostasis
and 9 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 91
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024