HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: CCR3 (P51677)
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Gene: CCR3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	8642344, 11449371, 10733106, 7622448
Identification Methods	pull down, experimental interaction detection, biochemical, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0005737 - cytoplasm GO:0006935 - chemotaxis GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 91 Hs			1 355
+	Hs
		486230 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		561728 CL3L1_HUMAN (1-91): 2.63e-37: 121: 46.74		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		526560 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		1305163 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		ACKR4_HUMAN (10-343): 1e-85: 264: 30.09
+	Hs
		486237 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		561732 CL3L1_HUMAN (1-91): 2.63e-37: 121: 46.74		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		526564 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		849619 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		783833 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CCR2_HUMAN (4-326): 8.26e-78: 245: 49.69
+	Hs
		486238 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CCR4_HUMAN (9-355): 3.59e-75: 237: 44.41
+	Hs
		486239 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		561733 CL3L1_HUMAN (1-91): 2.63e-37: 121: 46.74		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		526565 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		849654 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		134354 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134356 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134400 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		486231 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CXCR5_HUMAN (5-318): 3.6e-41: 149: 30.34
+	Hs
		830629 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36
+	Hs
		526561 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		CXCR5_HUMAN (5-318): 3.6e-41: 149: 30.34