HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.963

The method score is based on:

Property Details
Experiments 14637022, 11449371, 11116158, 9334377, 9207005, 10488147, 10477718, 23480650, 28381538
Identification Methods affinity chromatography technology, pull down, biochemical, experimental interaction detection, competition binding, nuclear magnetic resonance, fluorescence-activated cell sorting
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~IL8
Common GO terms GO:0002407 - dendritic cell chemotaxis
GO:0004435 - phosphatidylinositol phospholipase C activity
GO:0005737 - cytoplasm
GO:0006816 - calcium ion transport
GO:0006935 - chemotaxis
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 91
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024