HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: ACKR1 (Q16570)
Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234)
Gene: ACKR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	9195930, 7592830, 8132497
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 91 Hs			1 336
+	Mm
		677070 CCL5_MOUSE (1-91): 1.06e-35: 118: 80.22		ACKR1_MOUSE (1-336): 5.06e-93: 282: 59.82
+	Hs
		486231 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CXCR5_HUMAN (55-319): 3.59e-71: 227: 17.75
+	Hs
		486237 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CCR3_HUMAN (38-320): 6.5e-71: 225: 16.18
+	Hs
		561732 CL3L1_HUMAN (1-91): 2.63e-37: 121: 46.74		CCR3_HUMAN (38-320): 6.5e-71: 225: 16.18
+	Hs
		526561 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		CXCR5_HUMAN (55-319): 3.59e-71: 227: 17.75
+	Hs
		486239 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CCR5_HUMAN (32-319): 8.1e-70: 223: 17.09
+	Hs
		561733 CL3L1_HUMAN (1-91): 2.63e-37: 121: 46.74		CCR5_HUMAN (32-319): 8.1e-70: 223: 17.09
+	Hs
		526564 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		CCR3_HUMAN (38-320): 6.5e-71: 225: 16.18
+	Hs
		849619 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CCR3_HUMAN (38-320): 6.5e-71: 225: 16.18
+	Hs
		526565 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		CCR5_HUMAN (32-319): 8.1e-70: 223: 17.09
+	Hs
		849654 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CCR5_HUMAN (32-319): 8.1e-70: 223: 17.09
+	Hs
		486230 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CCR1_HUMAN (43-322): 4.76e-67: 216: 14.43
+	Hs
		561728 CL3L1_HUMAN (1-91): 2.63e-37: 121: 46.74		CCR1_HUMAN (43-322): 4.76e-67: 216: 14.43
+	Hs
		783833 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CCR2_HUMAN (16-322): 3.69e-68: 219: 17.07
+	Hs
		526560 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		CCR1_HUMAN (43-322): 4.76e-67: 216: 14.43
+	Hs
		486238 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		CCR4_HUMAN (20-324): 3e-64: 208: 15.85
+	Hs
		830629 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CXCR3_HUMAN (27-315): 3.94e-25: 105: 19.49
+	Hs
		134354 CCL3_HUMAN (1-91): 3.36e-37: 121: 49.45		ACKR2_HUMAN (63-325): 2.7e-21: 95.1: 19.79
+	Hs
		134356 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		ACKR2_HUMAN (63-325): 2.7e-21: 95.1: 19.79
+	Hs
		134400 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		ACKR2_HUMAN (63-325): 2.7e-21: 95.1: 19.79