HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: CXL17 (Q6UXB2)
C-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
Gene: CXCL17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	28381538
Identification Methods	pull down, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0010759 - positive regulation of macrophage chemotaxis GO:0048246 - macrophage chemotaxis GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0090026 - positive regulation of monocyte chemotaxis
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 91 Hs			1 119
+	Hs
		1166407 CCL13_HUMAN (1-90): 5.7e-36: 118: 31.87		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		945620 CCL8_HUMAN (1-90): 4.78e-31: 106: 36.96		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		528221 CCL2_HUMAN (1-90): 2.17e-27: 97.3: 33.70		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		1166410 CCL26_HUMAN (21-89): 8.09e-25: 90.8: 40.58		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		1166406 CCL17_HUMAN (1-89): 3.41e-23: 86.5: 28.09		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		815515 XCL1_HUMAN (1-90): 3.92e-22: 84.2: 33.33		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		1166409 XCL2_HUMAN (1-90): 7.46e-22: 83.8: 33.33		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		179467 CCL25_HUMAN (8-89): 5.78e-19: 77.3: 28.89		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		134308 CCL21_HUMAN (23-91): 1.24e-18: 76.1: 28.77		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00
+	Hs
		944668 CCL20_HUMAN (3-90): 5.27e-18: 73.4: 28.89		CXL17_HUMAN (1-119): 5.21e-77: 224: 100.00