HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 590
+	Hs
		528683 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K22E_HUMAN (140-484): 3.01e-174: 509: 71.88
+	Hs
		408988 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C8_HUMAN (140-516): 1.46e-162: 474: 69.23
+	Hs
		444525 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C7_HUMAN (74-494): 9.68e-163: 474: 65.09
+	Mm
		514315 CFTR_MOUSE (1-1468): 0: 957: 78.29		K2C8_MOUSE (140-537): 3.29e-162: 473: 64.66
+	Hs
		529780 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT84_HUMAN (1-570): 8.02e-100: 317: 48.26
+	Hs
		318772 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C75_HUMAN (1-567): 1.7e-95: 304: 69.67
+	Hs
		529119 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT81_HUMAN (56-576): 6.11e-86: 278: 45.68
+	Hs
		528963 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT85_HUMAN (1-528): 7.95e-85: 275: 47.55
+	Hs
		380440 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6B_HUMAN (2-503): 6.66e-84: 274: 79.08
+	Hs
		528760 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6C_HUMAN (2-503): 1.6e-83: 273: 78.69
+	Hs
		213928 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT86_HUMAN (49-483): 4.59e-84: 272: 50.81
+	Hs
		359458 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6A_HUMAN (2-563): 4.45e-79: 261: 74.20
+	Hs
		529130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C72_HUMAN (1-554): 4.32e-76: 252: 53.07
+	Hs
		529332 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C74_HUMAN (1-557): 9.58e-74: 246: 52.96
+	Hs
		529349 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C1B_HUMAN (36-499): 1.21e-66: 229: 60.35
+	Hs
		529503 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT35_HUMAN (52-526): 5.44e-65: 221: 23.37