HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	26618866, 29924966, 31324722
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009986 - cell surface GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 645
+	Hs
		423122 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11
+	Hs
		529142 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51
+	Hs
		528620 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35
+	Hs
		529425 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48