HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	26618866, 31324722, 29924966
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 475
+	Hs
		528467 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17
+	Hs
		529691 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TRIM5_HUMAN (1-466): 9.08e-121: 363: 40.04
+	Hs
		529591 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ERMAP_HUMAN (287-463): 2.47e-57: 198: 55.37